Gas Chromatography is a type of chromatography used for analyzing compounds that are volatile or can be vaporized at higher temperatures without decomposition. Organic compounds with ionizable functional groups, such as alcohols, amines, carboxylic acids, are often not volatile enough for use with GC, however, they can be easily derivatized via silylation, methylation, etc. to generate volatile derivatives for GC-based analysis.
GC-MS and GC-FID techniques are performed at Emery Pharma with customized method development, validation, method transfer (USP, EP, BP, JP, etc.), library matching for unknown analytes, and custom analyte library generation. We specialize in detecting and quantifying low parts per million (10-6, ppm) and ultra-trace levels of analytes, i.e. sensitivity in the range of ppb or parts per billion (10-9), from complex mixtures.
Emery Pharma utilizes GC-MS and GC-FID techniques in both liquid injection and thermal desorption methods (including SPME) and USP/FDA Headspace sampling for volatile impurities including residual solvents. We are experienced in derivatization sample prep for poorly volatile analytes.
We are happy to be the partnering lab for clients requiring analysis of hard to solve problems. Please contact us today to learn more about our services and let us know how we can be your bridge to success on your next analytical project.