What is Metabolomics?
Metabolomics is broadly defined as the comprehensive measurement of all metabolites and low-molecular-weight molecules in a biological sample.
A metabolite is an intermediate or end product of metabolism. Endogenous metabolites (not to be confused with drug metabolites) represent a diverse group of chemical compounds that are naturally produced in the body, including lipids, amino acids, peptides, nucleic acids, and organic acids. Metabolites and their concentrations can reflect the biochemical activity and state of cells or tissues. On the other hand, drug metabolites result from metabolizing a drug by the body. Metabolites can also form from the foods we consume, the microbiota in the body, as well as many chemical processes that occur in a biological system. Metabolomics broadly encompasses all such classes of metabolites present in a biological sample.
Practical applications of metabolomics include:
- Activity information about possible novel drugs and drug scaffolds
- Identify targets for drug development and suggest binding partners of compounds
- Pre-clinical biomarker identification
- Discovery of novel natural products
At Emery Pharma, we have a comprehensive platform with advanced instruments including UPLC-HR MS, GC-MS, UPLC-QqQ-MS/MS, and NMR to address all forms of untargeted and targeted metabolomics needs. Our metabolomics services support the pharmaceutical, biomedical, food, and agricultural industry. We are happy to support our clients with in-house assays or project-specific method development, implementation, and data analysis.
Our experienced team of analytical scientists can recommend the best testing and analysis procedure for your needs. If you have any questions or specific requirements, please don’t hesitate to contact us.