From method development to validation, our analytical chemistry experts can help quantitate and characterize a wide range of compounds to accelerate your drug development program.
Our state-of-the-art instrumentation include a High Resolution Orbitrap Mass Spectrometer, several triple quad LC-MS/MS systems, a Semi-Preparative High-Performance Liquid Chromatography (HPLC), a Gas Chromatography Mass Spectrometry (GC-MS/FID System) system, and an Ultrahigh Pressure Liquid Chromatography (UPLC) equipped with a Charged Aerosol Detector (CAD) and Refractive Index (RI) detector.
What Analytical Services Do We Offer?
Emery Pharma Can Help
with Your Analytical Needs
Emery Pharma is a full-service contract research laboratory, specializing in supporting preclinical drug development, including analytical, bioanalytical solutions, microbiology & cell biology services, drug and impurity characterization, and general R&D and cGMP/GLP support. Emery Pharma provides exceptional analytical solutions for our Clients’ toughest R&D challenges and tailors those solutions to fit each Client’s unique needs.
High-performance liquid chromatography (HPLC) is a power-house analytical technique used for separation, identification, and quantitation of component(s) in a mixture. HPLC or the more advanced Ultrahigh-performance LC (UHPLC or UPLC) uses sophisticated pumps to pass a mobile phase at high pressures though a chromatography column, thereby allowing interaction of components with the adsorbent material of the column. Depending on the nature of the column/mobile phases, several variations of HPLC is possible, e.g., Reversed phase (RP), Hydrophilic interaction liquid chromatography (HILIC), Size exclusion chromatography (SEC), Ion exchange chromatography (IEX), etc.
HPLC is widely utilized for virtually all aspects and stages of drug discovery and development; additionally, the technique has extensive uses in environmental, clinical/diagnostic, manufacturing, cosmetics, and legal sample analyses.
At Emery Pharma, we employ a wide range of HPLC/UPLC techniques with variety of detectors for different analytes: mass spectrometry (LC-MS), UV-Vis (VWD, DAD), charged aerosol detectors (CAD), and refractive index (RI) – covering the gamut of HPLC/UPLC applications.
Liquid Chromatography Mass Spectrometry (LC-MS) is an analytical chemistry laboratory technique that can be used for identification, quantification, and mass analysis of samples and materials. LC-MS couples the power of high-performance liquid chromatography (HPLC) with a mass spectrometer (MS). At Emery Pharma, our tandem LC-MS (LC-MS/MS) is especially powerful in detecting and quantifying a variety of molecules. This triple-quadropole system measures, breaks down, filters, and measures again the compound of interest, allowing us incredibly low levels of detection, detection in not-so-pure samples, and highly accurate and specific detection of the compound.
Nuclear Magnetic Resonance (NMR) Spectroscopy is an analytical chemistry laboratory technique used to look at the chemical environments of a selected nucleus (typically 1H) on a molecular level. NMR is often used for chemical structure characterization of liquids and dissolved solids, deformulation of products, and quantification of mixture components. Our NMR services are designed to cover a full spectrum of possibilities from a basic 1H NMR analysis with minimal processing, to complete structure analysis (including a full range of 2D NMR) and interpretations.
Emery Pharma offers bioanalytical services such as comprehensive, state-of-the-art method development, method transfer, method validation, and sample and metabolite analysis. Our bioanalytical laboratory scientists offer a high level of expertise in developing exceedingly accurate and robust HPLC methods that enable us to offer proprietary assays and assay development for biological samples analysis including but not limited to blood plasma, serum, tissue, urine and feces, as well as raw materials, formulated products and environmental samples.
Metabolomics is broadly defined as the comprehensive measurement of all metabolites and low-molecular-weight molecules in a biological sample. A metabolite is an intermediate or end product of metabolism. Endogenous metabolites (not to be confused with drug metabolites) represent a diverse group of chemical compounds that are naturally produced in the body, including lipids, amino acids, peptides, nucleic acids, and organic acids. Metabolites and their concentrations can reflect the biochemical activity and state of cells or tissues.
Proteomics is the study of the proteome, the entire set of proteins produced by a living system. It involves identification of proteins, investigation of protein abundances, the variations, and modifications therein, as well as insight into interacting partners and networks.
Medicinal Chemistry Support
Our expertise in diverse therapeutic areas covers all aspects of medicinal chemistry, from strategic planning to hit evaluation and validation to lead optimization and pre-clinical development. Analysis by USP monograph procedures, such as HPLC assay, related substance, identification, uniformity, loss on drying, osmolality, and pH are also available.
Gas Chromatography (GC) is used for analyzing compounds that are volatile or can be vaporized at higher temperatures without decomposition, either in their native form (e.g., odorous oils, organic solvents) or converted to a volatile derivative (e.g., alcohols, amines, carboxylic acids via silylation, methylation, etc.).
GC is indispensable for drug discovery and development (e.g., residual solvents, genotoxic impurities such as nitrosamines, benzene, DMF), Research (metabolomics, chemical synthesis), Environmental analyses (emerging contaminants: pesticides, polyphenolic compounds, PAHs, PCBs, etc.), food, beverage, and fragrance analysis
Several detectors are used for GC, most commonly Flame ionization detector (FID) and Mass spectrometry (MS). GC-MS and GC-FID techniques are performed at Emery Pharma with customized method development, validation, method transfer (USP, EP, BP, JP, etc.), library matching for unknown analytes, and custom analyte library generation. We utilize both liquid injection and thermal desorption methods (including SPME) and USP/FDA Headspace sampling, as well as derivatization poorly volatile analytes.