Prep-LC and flash chromatography is used to isolate desired compounds or impurities for subsequent evaluation and/or structural determination. Our wide range of reverse-phase columns (C18 columns up to 3 inches internal diameter and 2 feet long!) allows us to work with sample sizes from 10 mg to 5 grams per run. If you have an R&D project that requires isolation of natural products from complex matrices, such as plant material or microbial culture media, we can help. Isolation of decomposition impurities from a drug product is another one of our specialties. If you are at the pre-registration stage with the FDA, EMA, or Japan PMDA and there are specific requirements for characterization, we can provide you with full service characterization of your active pharmaceutical ingredient (API) and minor impurities.