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Antibody Drug Conjugates Q&A: A Novel Approach to Drug Delivery in Oncology

What is an antibody drug conjugate? An antibody drug conjugate, or ADC, is a drug modality that consists of three main components: an antibody, a linker, and a drug, often…

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Native Mass Spectrometry (Native-MS) for Aggregate and Charge Variant Analysis

Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) are traditional methods utilized for characterizing biotherapeutics under non-denaturing conditions. The typical high salt concentrations in their mobile phases make them…

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A Guide to Quantitative NMR (qNMR)

Quantitative NMR (qNMR) stands as a robust method for gauging pharmaceutical purity. In the realm of analytical chemistry, nuclear magnetic resonance (NMR) spectroscopy emerges as a potent technique, offering insights…

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The Past, Present and Future of ADCs

ADCs, short for antibody-drug conjugates, consist of three essential components: a monoclonal antibody (mAb), a linker molecule, and a small molecule drug. In simple terms, an ADC is created by…

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Microbial Warriors: A New Hope in the Fight Against Cancer

Cancer is a complex disease that requires a multifaceted approach to treatment in order to prevent regression. In the past, traditional treatments in oncology have consisted of small molecule cytotoxic…

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A Step-by-Step Guide to Analytical Method Development and Validation

Method development and validation are essential components of drug development and chemistry manufacturing and controls (CMC). The goal of method development and validation is to  ensure that the methods used…

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Characterization of Biologic Drugs: An Overview

Intact Mass and Subunit Fragment Analyses The LC-MS analyses of the intact and subunit biologic molecules are simple analyses which characterize detailed modifications of complex molecules.  This information-rich study is…

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The Very Standard Kilogram

Gravimetry, the science of measuring weight plays a critical role in Analytical Sciences. All analytical chemistry labs are equipped with one or more calibrated scientific balances to measure weight. Specifically,…

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Infection by Site

Choosing the Right Bacteria and Antibiotic in Novel Anti-infective Discovery The development of new drugs to treat infectious disease requires a great understanding of bacteria and their primary sites of…

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Nailing the Science Behind CBD

Introduction Cannabidiol (CBD) is a non-psychoactive compound, derived from the Cannabis plant, that can be extracted either for medicinal use or as a nutritional supplement. Over the years, there is…

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