Ensuring Quality and Efficacy of GLP-1 Agonists: Analytical Challenges and Solutions in Therapeutic Peptide Production
Glucagon-like peptide-1 (GLP-1) agonists represent an exciting class of drugs that have gained significant attention in recent years for their…
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Antibody Drug Conjugates Q&A: A Novel Approach to Drug Delivery in Oncology
What is an antibody drug conjugate? An antibody drug conjugate (ADC) is an innovative drug modality that consists of three…
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Native Mass Spectrometry (Native-MS) for Aggregate and Charge Variant Analysis
Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) are traditional methods utilized for characterizing biotherapeutics under non-denaturing conditions. The…
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A Guide to Quantitative NMR (qNMR)
Quantitative NMR (qNMR) stands as a robust method for gauging pharmaceutical purity. In the realm of analytical chemistry, nuclear magnetic…
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The Past, Present and Future of ADCs
ADCs, short for antibody-drug conjugates, consist of three essential components: a monoclonal antibody (mAb), a linker molecule, and a small…
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Microbial Warriors: A New Hope in the Fight Against Cancer
Cancer is a complex disease that requires a multifaceted approach to treatment in order to prevent regression. In the past,…
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A Step-by-Step Guide to Analytical Method Development and Validation
Method development and validation are essential components of drug development and chemistry, manufacturing, and controls (CMC). The goal of method…
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Characterization of Biologic Drugs: An Overview
Intact Mass and Subunit Fragment Analyses The LC-MS analyses of the intact and subunit biologic molecules are simple analyses which…
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The Very Standard Kilogram
Gravimetry, the science of measuring weight, plays a critical role in analytical sciences. All analytical chemistry labs are equipped with…
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Infection by Site
Choosing the Right Bacteria and Antibiotic in Novel Anti-infective Discovery The development of new drugs to treat infectious diseases requires…
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