Ensuring Quality and Efficacy of GLP-1 Agonists: Analytical Challenges and Solutions in Therapeutic Peptide Production
Glucagon-like peptide-1 (GLP-1) agonists represent an exciting class of drugs that have gained significant attention in recent years for their…
Antibody Drug Conjugates Q&A: A Novel Approach to Drug Delivery in Oncology
What is an antibody drug conjugate? An antibody drug conjugate (ADC) is an innovative drug modality that consists of three…
Native Mass Spectrometry (Native-MS) for Aggregate and Charge Variant Analysis
Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) are traditional methods utilized for characterizing biotherapeutics under non-denaturing conditions. The…
A Guide to Quantitative NMR (qNMR)
Quantitative NMR (qNMR) stands as a robust method for gauging pharmaceutical purity. In the realm of analytical chemistry, nuclear magnetic…
The Past, Present and Future of ADCs
ADCs, short for antibody-drug conjugates, consist of three essential components: a monoclonal antibody (mAb), a linker molecule, and a small…
Microbial Warriors: A New Hope in the Fight Against Cancer
Cancer is a complex disease that requires a multifaceted approach to treatment in order to prevent regression. In the past,…
A Step-by-Step Guide to Analytical Method Development and Validation
Method development and validation are essential components of drug development and chemistry, manufacturing, and controls (CMC). The goal of method…
Characterization of Biologic Drugs: An Overview
Intact Mass and Subunit Fragment Analyses The LC-MS analyses of the intact and subunit biologic molecules are simple analyses which…
The Very Standard Kilogram
Gravimetry, the science of measuring weight, plays a critical role in analytical sciences. All analytical chemistry labs are equipped with…
Infection by Site
Choosing the Right Bacteria and Antibiotic in Novel Anti-infective Discovery The development of new drugs to treat infectious diseases requires…