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In the world of analytical chemistry, selecting the right technique can be the key to unlocking precise and meaningful results. Two giants dominate this landscape: Liquid Chromatography-Mass Spectrometry (LCMS) and Gas Chromatography-Mass Spectrometry (GCMS) . Each method has its unique…
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The analysis of proteins covalently linked to small molecules has become a cornerstone of drug discovery, therapeutic development, and biological research. These small molecules can form stable, irreversible complexes with proteins through covalent bonding, often affecting the protein’s function, stability,…
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Cell-based assays are vital for understanding cellular responses to drugs, environmental factors, and genetic changes, making them crucial for drug development, toxicity testing, and biomarker discovery. At Emery Pharma, we leverage our expertise in biology and chemistry, using advanced cell…
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Antibody Drug Conjugates (ADCs) represent an innovative class of targeted cancer therapies that combine the specificity of antibodies with the potency of cytotoxic drugs. By delivering chemotherapeutic agents directly to tumor cells while minimizing toxicity to healthy tissue, ADCs offer…
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The selection of a bioanalytical platform is critical because it directly influences the accuracy, sensitivity, and specificity of the data generated, which in turn guides decision-making in drug development. A well-chosen platform ensures reliable quantification and characterization of biomolecules, minimizes…
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What is an antibody drug conjugate? An antibody drug conjugate (ADC) is an innovative drug modality that consists of three main components: an antibody, a linker, and a drug, often referred to as a “payload” due to its cytotoxic nature.…
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Size exclusion chromatography (SEC) and ion exchange chromatography (IEX) are traditional methods utilized for characterizing biotherapeutics under non-denaturing conditions. The typical high salt concentrations in their mobile phases make them incompatible with mass spectrometry (MS) detection. Native-MS stands out as…
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ADCs, short for antibody-drug conjugates, consist of three essential components: a monoclonal antibody (mAb), a linker molecule, and a small molecule drug. In simple terms, an ADC is created by joining an antibody (mAb) with a drug through a linker…
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Intact Mass and Subunit Fragment Analyses LC-MS analyses of intact and subunit biologic molecules are essential tools for characterizing the detailed modifications of complex proteins and peptides. These information-rich analyses are utilized throughout the product development lifecycle, including GMP release…
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If you are developing a gene-therapy-based product, which requires a Poloxamer quantitation assay, and if you are a sponsor of investigational new drug applications (INDs) or applicant of new drug applications (NDAs) that require Poloxamers testing as part of your…
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